The steely-nerved keeper is widely considered among the greatest goalkeepers, after she recorded 12 clean sheets and allowed only a dozen goals in 22 starts at the World Cup and Olympics.
She will play her final two games with the US team, friendlies against England and the Netherlands, in London on November 30th and The Hague on December 3rd, respectively.
"When I began this journey, I never could have imagined where it would take me, and now I find myself so grateful for all the incredible teammates that I have shared the field with," the twice World Cup winner said in a statement.
"This has been a special team to be a part of and I am beyond proud of what we have achieved both on and off the field."
Naeher, who earned her 100th cap this year after a decade of donning the red, white and blue, intends to play the 2025 season with the NWSL side Chicago Stars.