City remain without Manuel Akanji, John Stones and Nathan Ake, while Rodri looks no closer to a return any time soon.
Meanwhile, Spurs are back to life without first-choice defensive pair Micky Van de Ven and Cristian Romero when they head to bottom side Southampton.
Elsewhere, Ollie Watkins seems unlikely to feature for Aston Villa as they head to high-flying Nottingham Forest, leaving the door ajar for super sub Jhon Duran to nail down a starting spot in Unai Emery's first XI.
Take a look at who's missing and who's questionable ahead of the next round of Premier League fixtures:
Arsenal v Everton
WON'T PLAY
Calafiori R. | Knee Injury
Tomiyasu T. | Knee Injury
White B. | Knee Injury
Garner J. | Lower Back Injury
Iroegbunam T. | Ankle Injury
QUESTIONABLE
Zinchenko O. | Muscle Injury
Chermiti | Ankle Injury
Liverpool v Fulham
WILL NOT PLAY
Bradley C. | Muscle Injury
Chiesa F. | Lacking Match Fitness
Diogo Jota | Chest Injury
Konate I. | Knee Injury
Mac Allister A. | Yellow Cards
Tsimikas K. | Ankle Injury
Andersen J. | Calf Injury
Bassey C. | Yellow Cards
Cairney T. | Red Card
Nelson R. | Thigh Injury
Reed H. | Knee Injury
Newcastle v Leicester
WILL NOT PLAY
Botman S. | Knee Injury
Krafth E. | Shoulder Injury
Lascelles J. | Knee Injury
Wilson C. | Thigh Injury
Fatawu I. | Knee Injury
Ndidi W. | Thigh Injury
Opoku N. | Broken Leg
Pereira R. | Thigh Injury
Soumare B. | Yellow Cards
Stolarczyk J. | Ankle Injury
QUESTIONABLE
Pope N. | Knee Injury
Willock J. | Thigh Injury
Winks H. | Muscle Injury
Wolves v Ipswich
WILL NOT PLAY
Chiwome L. | Ankle Injury
Gomes J. | Yellow Cards
Gonzalez E. | Knee Injury
Kalajdzic S. | Knee Injury
Mosquera Y. | Knee Injury
Traore B. | Knee Injury
Donacien J. | Ankle Injury
Hirst G. | Knee Injury
Ogbene C. | Calf Injury
Tuanzebe A. | Thigh Injury
QUESTIONABLE
Sa J. | Shoulder Injury
Sarabia P. | Muscle Injury
Nottingham Forest v Aston Villa
WILL NOT PLAY
Moreno A. | Loan Agreement
Sangare I. | Foot Injury
Ramsey J. | Hamstring Injury
QUESTIONABLE
Bailey L. | Thigh Injury
Watkins O. | Thigh Injury
Brighton v Crystal Palace
WILL NOT PLAY
Hinshelwood J. | Knee Injury
Kadioglu F. | Toe Injury
March S. | Knee Injury
Milner J. | Thigh Injury
Webster A. | Muscle Injury
Holding R. | Lacking Match Fitness
Matheus Franca | Muscle Injury
Riad C. | Knee Injury
Wharton A. | Groin Injury
QUESTIONABLE
Veltman J. | Muscle Injury
Manchester City v Manchester United
WILL NOT PLAY
Akanji M. | Injury
Ake N. | Thigh Injury
Bobb O. | Leg Injury
Lewis R. | Red Card
Rodri | Knee Injury
Stones J. | Health problems
Shaw L. | Calf Injury
QUESTIONABLE
Evans J. | Knock
Chelsea v Brentford
WILL NOT PLAY
Fofana W. | Muscle Injury
James R. | Thigh Injury
Kellyman O. | Muscle Injury
Neto P. | Yellow Cards
Dasilva J. | Knee Injury
Gustavo Nunes | Back Injury
Henry R. | Knee Injury
Hickey A. | Thigh Injury
Jensen M. | Thigh Injury
WILL NOT PLAY
Janelt V. | Injury
Southampton v Tottenham
WILL NOT PLAY
Bazunu G. | Achilles Tendon Injury
Lallana A. | Thigh Injury
Larios J. | Injury
Smallbone W. | Thigh Injury
Stephens J. | Red Card
Stewart R. | Thigh Injury
Bentancur R. | Suspended
Bissouma Y. | Yellow Cards
Davies B. | Thigh Injury
Odobert W. | Thigh Injury
Richarlison | Thigh Injury
Romero C. | Ankle Injury
Van de Ven M. | Injury
Vicario G. | Broken ankle
QUESTIONABLE
Ramsdale A. | Finger Injury
Bournemouth v West Ham
TBD