The game had been scheduled to take place at Red Star Belgrade's Stadion Rajko Mitic, but has now been relocated to the Puskas Arena in Budapest.
The reason for the switch was not given by European ruling body.
UEFA postponed all matches in Israel in October due to the security situation following the start of the country's war with Hamas.
Haifa are bottom of Group F with one point from three matches. Rennes top the group on nine points.