Using our internal ratings system and considering players who featured for at least 60 minutes across both legs, here's who makes the latest Team of the Round.
Goalkeeper
Diogo Costa (Porto) 8.2
Costa was imperious between the sticks for Porto, as the Portuguese giants proved too strong for Stuttgart to convincingly seal their place in the quarter-finals.
The 26-year-old shot-stopper made an impressive 12 saves across the two legs, keeping his third clean sheet of the tournament in the process.
Defence
Zakaria El Ouahdi (Genk) 8.6
Despite winning the first leg on home soil, Genk were ultimately outclassed in Germany, as they fell to a disappointing 5-2 aggregate defeat against Bundesliga side Freiburg.
Right-back El Ouahdi was the match-winner for De Smurfen in Belgium with a clinical volley, but a costly yellow card meant he was forced to sit out the return leg.
Marc Bartra (Real Betis) 7.9
Bartra was influential in defence for Real Betis as the LaLiga outfit overturned a first-leg deficit to overwhelm Panathinaikos in a 4-1 aggregate triumph.
The experienced Spaniard made nine clearances during the second leg in Andalusia, while also contributing a further four interceptions and an impressive pass success rate of 90%.
Daniele Ghilardi (Roma) 7.6
Considered one of the favourites for the trophy, Roma were surprisingly sent packing in the last-16 stage after a dramatic 5-4 aggregate defeat to fellow Italian side Bologna.
Centre-back Ghilardi was a standout performer for the Giallorossi in a closely fought first leg, with the Italian winning seven ground duels and making five key clearances.
Midfield
Antony (Real Betis) 7.9
Antony continues to produce the goods for Betis this season, as the Brazilian played a leading role in his side's second-leg thrashing of Panathinaikos.
The former Manchester United man won eight ground duels, completed all three of his dribbles, and got his name on the scoresheet with a neat close-range finish.
Lorenzo Pellegrini (Roma) 8.2
Despite starting both legs against Bologna on the bench, Pellegrini couldn't have contributed more for Gian Piero Gasperini's side, with a couple of excellent substitute appearances.
The midfielder netted an important equaliser for Roma in Emilia-Romagna, before scoring and assisting in the Giallorossi's agonising second-leg defeat.
James McAtee (Nottingham Forest) 7.9
McAtee was handed a rare start for Nottingham Forest in their second leg against FC Midtjylland, and the 23-year-old certainly took his opportunity.
Not only did he provide an assist for Ryan Yates' goal, but he also won five ground duels and completed 83% of his passes in the final third.
Abde Ezzalzouli (Real Betis) 7.9
The third Betis player to make our team is winger Ezzalzouli, who turned on the style in his side's emphatic 4-0 victory over Panathinaikos.
The Moroccan was a constant threat for Manuel Pellegrini's men, completing four successful dribbles as well as unselfishly setting up Antony for Betis' fourth goal.
Attack
Konstantinos Karetsas (Genk) 7.8
While Genk were comfortably beaten by Freiburg over two legs, Greek teenager Karetsas provided a silver lining for the Belgians with a couple of eye-catching displays.
The 18-year-old was particularly impressive in the second leg, laying on a neat pass for Matte Smets' goal - his fourth assist of the tournament.
Ricardo Horta (Braga) 7.9
Faced with a two-goal deficit after the first leg in Budapest, Braga mounted a superb comeback on home soil to overcome Hungarian side Ferencvaros 4-2 on aggregate.
Horta spearheaded the Archbishops' revival with two goals in the second leg, including a brilliant curled finish from the edge of the box.
Federico Bernardeschi (Bologna) 7.8
Former Juventus star Bernardeschi rolled back the years for Bologna in their thrilling last-16 tie against Roma, with the forward scoring crucial goals in both legs.
He also won 11 ground duels across the two matches, as well as making three tackles and completing six dribbles.