Lamine Yamal suffered the injury while on international duty with Spain and Barca boss Hansi Flick slammed the national team for not taking better care of the 18-year-old, who also missed the weekend LaLiga win over Valencia.
Apart from Lamine Yamal, who started the season strongly with two goals and two assists in LaLiga, Barcelona said on Wednesday that Alejandro Balde and Gavi are also out along with long-term absentee Marc-Andre ter Stegen but Frenkie de Jong is available.
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Barca were knocked out in the semi-finals last term while Newcastle are back in the Champions League after failing to qualify for last season's competition.