The experienced Adams and Williams missed much of last season with injury as Wales seek to end a dismal team record run of 12 defeats in a row dating back to the 2023 Rugby World Cup that has put coach Warren Gatland’s position under the spotlight.
Wing Tom Rogers makes up the remainder of the back three, with Owen Watkin and Nick Tompkins the centre-pairing.
Scrum-half Tomos Williams will be alongside Thomas, the latter picked due to an injury to Sam Costelow and the desire to look at other options beyond Gareth Anscombe.
The side will be captained by Jac Morgan, who has James Botham and number eight Aaron Wainwright with him at the back of the scrum.
Will Rowlands and Jenkins are the lock pairing and hooker Evan Lloyd is joined by props Gareth Thomas and Henry Thomas in the front row.
"We’re excited for the challenge on Friday. The Six Nations is the best rugby competition in the world," Gatland said. "Every game is a big occasion. We want to go out there, embrace that and start our championship well."
Welsh Team
15-Liam Williams, 14-Tom Rogers, 13-Nick Tompkins, 12-Owen Watkin, 11-Josh Adams, 10-Ben Thomas, 9-Tomos Williams, 8-Aaron Wainwright, 7-Jac Morgan (captain), 6-James Botham, 5-Dafydd Jenkins, 4-Will Rowlands, 3-Henry Thomas, 2-Evan Lloyd, 1-Gareth Thomas
Replacements: 16-Elliot Dee, 17-Nicky Smith, 18-Keiron Assiratti, 19-Freddie Thomas, 20-Tommy Reffell, 21-Rhodri Williams, 22-Dan Edwards, 23-Blair Murray.