Littler will be aiming to become only the second player in history to successfully defend the Premier League title, a daunting task against a field of the world's elite.
Joining the 18-year-old and the Green Machine will be a star-studded line-up including world number one Luke Humphries, former world champions Rob Cross and Gerwyn Price, and fan favourites Nathan Aspinall, Chris Dobey, and Stephen Bunting.
The format remains unchanged, with eight players competing in 16 mini-tournaments across the UK and Ireland, the Netherlands and Germany.
Each night will see a thrilling knockout format, with players battling through quarter-finals, semi-finals, and a final played over the best of 11 legs.
Points are awarded for each night's performance – five to the winner, three to the runner-up, and two to the semi-finalists – with the top four players in the league table advancing to the coveted Play-Offs at London's O2 Arena.
At the finale in London, the final four will battle it out for the prestigious Premier League crown on Thursday, May 29th.
The prize money for the 2025 edition of the tournament remains at £1 million, and there is a £10,000 bonus to each night's winner.
The outright tournament winner will take home £275,000, while the runner-up will receive £125,000.
You can follow all the action from every night of the Premier League with Flashscore, with the first night in Belfast kicking off proceedings on February 6th.
BetMGM Premier League schedule in full:
Night One - Thursday, February 6th
The SSE Arena, Belfast
Quarter-Finals
Chris Dobey v Gerwyn Price
Stephen Bunting v Rob Cross
Luke Littler v Michael van Gerwen
Nathan Aspinall v Luke Humphries
Night Two - Thursday, February 13th
OVO Hydro, Glasgow
Quarter-Finals
Rob Cross v Luke Littler
Michael van Gerwen v Stephen Bunting
Nathan Aspinall v Gerwyn Price
Luke Humphries v Chris Dobey
Night Three - Thursday, February 20th
3Arena, Dublin
Quarter-Finals
Luke Humphries v Stephen Bunting
Gerwyn Price v Luke Littler
Rob Cross v Nathan Aspinall
Michael van Gerwen v Chris Dobey
Night Four - Thursday, February 27th
Westpoint Exeter
Quarter-Finals
Michael van Gerwen v Rob Cross
Gerwyn Price v Luke Humphries
Chris Dobey v Nathan Aspinall
Stephen Bunting v Luke Littler
Night Five - Thursday, March 6th
The Brighton Centre
Quarter-Finals
Gerwyn Price v Michael van Gerwen
Luke Littler v Chris Dobey
Rob Cross v Luke Humphries
Stephen Bunting v Nathan Aspinall
Night Six - Thursday, March 13th
Motorpoint Arena, Nottingham
Quarter-Finals
Luke Humphries v Luke Littler
Rob Cross v Chris Dobey
Stephen Bunting v Gerwyn Price
Nathan Aspinall v Michael van Gerwen
Night Seven - Thursday, March 20th
Utilita Arena, Cardiff
Quarter-Finals
Chris Dobey v Stephen Bunting
Luke Humphries v Michael van Gerwen
Luke Littler v Nathan Aspinall
Gerwyn Price v Rob Cross
Night Eight - Thursday, March 27th
Utilita Arena, Newcastle
Draw Bracket based on league table following Night Seven
Night Nine - Thursday, April 3rd
Uber Arena, Berlin
Quarter-Finals
Nathan Aspinall v Stephen Bunting
Luke Humphries v Rob Cross
Chris Dobey v Luke Littler
Michael van Gerwen v Gerwyn Price
Night Ten - Thursday, April 10th
AO Arena, Manchester
Quarter-Finals
Chris Dobey v Michael van Gerwen
Nathan Aspinall v Rob Cross
Luke Littler v Gerwyn Price
Stephen Bunting v Luke Humphries
Night 11 - Thursday, April 17th
Rotterdam Ahoy
Quarter-Finals
Chris Dobey v Luke Humphries
Gerwyn Price v Nathan Aspinall
Stephen Bunting v Michael van Gerwen
Luke Littler v Rob Cross
Night 12 - Thursday, April 24th
M&S Bank Arena, Liverpool
Quarter-Finals
Luke Humphries v Nathan Aspinall
Michael van Gerwen v Luke Littler
Rob Cross v Stephen Bunting
Gerwyn Price v Chris Dobey
Night 13 - Thursday, May 1st
Utilita Arena, Birmingham
Quarter-Finals
Luke Littler v Stephen Bunting
Nathan Aspinall v Chris Dobey
Luke Humphries v Gerwyn Price
Rob Cross v Michael van Gerwen
Night 14 - Thursday, May 8th
First Direct Arena, Leeds
Quarter-Finals
Rob Cross v Gerwyn Price
Nathan Aspinall v Luke Littler
Michael van Gerwen v Luke Humphries
Stephen Bunting v Chris Dobey
Night 15 - Thursday, May 15th
P&J Live, Aberdeen
Quarter-Finals
Michael van Gerwen v Nathan Aspinall
Gerwyn Price v Stephen Bunting
Chris Dobey v Rob Cross
Luke Littler v Luke Humphries
Night 16 - Thursday, May 22nd
Utilita Arena, Sheffield
Draw Bracket based on league table following Night 15
Play-Offs - Thursday, May 29th
The O2, London
Semi-Finals & Final