Pirates must face debutants La Cure Waves of Mauritius in the first preliminary round. Should they advance, they will take on the winner of the clash between Mangasport of Gabon and African Stars of Namibia in the next stage.
If they win that tie, they will reach the group stages.
Sundowns have a bye through the first round and will await the winner of the tie between Wiliete of Angola and Foresters FC of Seychelles. They will, in all likelihood, face the Angolans.
The First Preliminary Round opening legs will be played from September 4-6, with the return matches scheduled for September 11-13.
The Second Preliminary Round will begin from October 16-18, before the decisive return legs are staged from October 23-25.
First Preliminary Round
Wiliete (Angola) vs Foresters FC (Seychelles)
Scottland FC (Zimbabwe) vs Nsingizini Hotspurs (Eswatini)
UD do Songo (Mozambique) vs Atlético Petróleos (Angola)
AS Mangasport (Gabon) vs African Stars (Namibia)
La Cure Waves (Mauritius) vs Orlando Pirates FC (South Africa)
15 de Agosto (Equatorial Guinea) vs Fomboni FC (Comoros)
Mighty Wanderers (Malawi) vs Simba SC (Tanzania)
CFFA (Madagascar) vs Lijabatho FC (Lesotho)
Gaborone United FC (Botswana) vs Young Africans SC (Tanzania)
Swehly SC (Libya) vs KVZ FC (Zanzibar)
Aigles du Congo (DR Congo) vs APR FC (Rwanda)
AS Port (Djibouti) vs Zamalek SC (Egypt)
El Merriekh Bentiu (South Sudan) vs Heegan SC (Somalia)
Gor Mahia FC (Kenya) vs Pyramids FC (Egypt)
Aiglons FC (Chad) vs Sidaama Buna (Ethiopia)
Aigle Noir CS (Burundi) vs Al Hilal SC (Sudan)
Star Sport Academy (Sierra Leone) vs Medina United FC (The Gambia)
MAS de Fès (Morocco) vs Rahimo FC (Burkina Faso)
ASCK (Togo) vs ASEC Mimosas (Côte d’Ivoire)
FC Canchungo (Guinea-Bissau) vs Teungueth FC (Senegal)
Colombe Sportive (Cameroon) vs Stade Malien (Mali)
Rangers International FC (Nigeria) vs SOBEMAP FC (Benin)
ASN Nigelec (Niger) vs MC Alger (Algeria)
FC San Pedro (Côte d’Ivoire) vs Rivers United (Nigeria)
Vipers SC (Uganda) vs FC Nouadhibou (Mauritania)
JS Saoura (Algeria) vs Horoya AC (Guinea)
Al Merriekh SC (Sudan) vs Power Dynamos (Zambia)
Medeama SC (Ghana) vs TP Mazembe (DR Congo)
Club Africain (Tunisia) vs Djoliba AC (Mali)
Second Preliminary Round
Wiliete or Foresters FC vs Mamelodi Sundowns (South Africa)
Scottland FC or Nsingizini Hotspurs vs UD do Songo or Atlético Petróleos
AS Mangasport or African Stars vs La Cure Waves or Orlando Pirates
15 de Agosto or Fomboni FC vs Mighty Wanderers or Simba SC
CFFA or Lijabatho FC vs Gaborone United FC or Young Africans SC
Swehly SC or KVZ FC vs Espérance Sportive de Tunis (Tunisia)
Aigles du Congo or APR FC vs AS Port or Zamalek SC
El Merriekh Bentiu or Heegan SC vs Gor Mahia FC or Pyramids FC
Aiglons FC or Sidaama Buna vs Aigle Noir CS or Al Hilal SC
Star Sport Academy or Medina United FC vs RS Berkane (Morocco)
MAS de Fès or Rahimo FC vs ASCK or ASEC Mimosas
FC Canchungo or Teungueth FC vs Colombe Sportive or Stade Malien
Rangers International FC or SOBEMAP FC vs ASN Nigelec or MC Alger
FC San Pedro or Rivers United vs Vipers SC or FC Nouadhibou
JS Saoura or Horoya AC vs Al Merriekh SC or Power Dynamos
Medeama SC or TP Mazembe vs Club Africain or Djoliba AC